Study of Three Generations of Familial Adenomatous Polyposis, Treated Our Surgical Department

Yuji Yoshioka, Osamu Kojima, Ryouji Iizuka, Tetsuro Yamane, Toshio Takahashi

First Department of Surgery, Kyoto Prefectural University of Medicine

Familial adenomatous polyposis (FAP) surgically treated by the same department through three generations has not been previously reported in Japan. Studying eleven cases of FAP distributed through three generations, we came to the following conclusions: 1. Since carcinogenesis occurred earlier in later generations, sreening should begin at 15 to 20 years of age. 2. Postoperative follow-up of these patients is necessary for long-term monitoring of the upper gastrointestinal tract. 3. Examination of hypertrophy of the retinal pigment epithelium is considered to be effective for the early screening of FAP. 4. Chemoprevention of carcinogenesis of the unrescted rectum is considered to be essential after ileorectal anastomosis.

Key words
familial adenomatous polyposis, carcinogenesis, chemoprevention

Reprint requests
Yuji Yoshioka First Department of Surgery, Kyoto Prefectural University of Medicine
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602 JAPAN

Accepted
September 14, 1994

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