Analysis of Cell Proliferation Kinetics in Gastric Remnant Mucosa

Yong-Suk Chung, Kiyoshi Maeda, Naoyoshi Onoda, Itsuo Nakanishi, Shigehiko Nishimura, Akira Shigesawa, Toshiaki Kubo, Sei Sato, Masafumi Ogawa, Yasuyuki Kato, Kazuhiko Yoshikawa, Michio Sowa

First Department of Surgery, Osaka City University Medical School

The cell kinetics of epithelium in the gastric remnant were studied using several parameters including S phase cell population, PCNA labeling index and ODC activity in terms of portion, operative procedure (Billroth I or II) and duration after operation in 64 patients. PCNA LI and ODC activity in the stomal mucosa were significantly higher than in the greater curvature. This difference was especially pronounced in the group with the B-II procedure. Significantly higher PCNA LI and ODC activity of the stomal mucosa was recognized in the group with the B-II procedure than in that with the B-I procedure. PCNA LI and ODC activity of the stomal mucosa in B-II were significantly higher 5 or more years after surgery than less than 5 years after surgery, however those with B-I showed a contrasting tendency. Parameters in the group with a duration of 5 or more years with the B-II procedure showed significantly higher levels than the group with the B-I procedure. The present study showed that the cell kinetics of stomal mucosa in the gastric remnant were high, especially in the group with a duration of 5 or more years after surgery with the B-II procedure, sugesting that stomal mucosa in the gastric remnant reconstructed with the B-II procedure may have a high risk of promoting carcinogenesis.

Key words
gastric remnant mucosa, cell proliferation, Proliferating Cell Nuclear Antigen, Ornithine Decarboxylase

Reprint requests
Yong-Suk Chung First Department of Surgery, Osaka City University
1-5-7 Asahimachi, Abeno-ku, Osaka City, 545 JAPAN

Accepted
November 9, 1994

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