A Case Report of Anal Mucocellular Carcinoma Assosiated with Perianal Paget's Disease

Tatsuharu Yamada, Akihiro Yamaguchi, Masatoshi Isogai, Akihiro Hori, Yukoh Kin, Atsuyuki Maeda, Masami Kawai, Manabu Takano, Ryuzo Yamaguchi, Tomoyuki Kubota

Department of Surgery, Ogaki Municipal Hospital

Perianal Paget's disease is rare. Only twenty cases, including ours, have been reported in Japan, and almost all of them have been associated with malignant tumors. We describe one case of Paget's disease with anal cancer originating from anal glands. A 79-year-old man came to our hospital with chief complaints of anal tumor and bleeding. We found an anal tumor on the dentate line and perianal erosion. Biopsy of the anal tumor reveraled signet ring cell carcinoma, and abdominoperineal resection was performed. Histologically, the anal tumor was mucocellular carcinoma with mucous lake, and the perianal erosion was due to the intraepidermal spread of signet ring cells, i.e., Paget's cells. Based on the literature, we report that perianal Paget's disease shows a relationship with anal cancer originating from anal glands.

Key words
anal cancer, perianal Paget's disease

Reprint requests
Tatsuharu Yamada Department of Surgery, Ogaki Municipal Hospital
4-86 Minaminokawacho, Ogaki City, 503 JAPAN

Accepted
November 9, 1994

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