Effexts of "Bukuryo-in" on Early Anastomotic Stenosis after Gastrectomy

Yoshinobu Hattori¹⁾, Seisaku Kamibayashi²⁾, Hirofumi Satoh²⁾, Michihisa Kojima²⁾, Toru Watanabe³⁾, Kenji Omura³⁾

¹⁾Kijima Hospital
²⁾Department of Surgery, Yokohama Sakae Kyosai Hospital
³⁾First Department of Surgery, Kanazawa University School of Medicine

Patients with early anastomotic stenosis after gastrectomy were treated with the Kampo medicine Bukuryo-in. We investigated histologically the anastomosis of rats treated with Kampo medicine. Of 64 patients who underwent gastrectomy, 25 complained of stenotic symptoms within four weeks after surgery. Fourteen of these 25 patients were treated with Bukuryo-in (group A), and the remaining 11 had no treatment (group B). Of 14 patients treated with Bukuryo-in, 12 experienced relief of stenotic symptoms within a week. The duration of the symptoms was five days in grop A, significantly shorter than 13.2 days in group B. There was no significant difference in dilatation of the gastric remnant, or passage through the anastomosis as evaluated by Gastrografin between groups A and B. Billroth I anastomosis was performed on Donryu rats, and they were divided into three groups: eight rats treated with Bukuryoin, eight with Rikkunshi-to, and five with water. We investigated the volume of the gastric remnant, pH of the gastric juice, and histology of the anastomosis 5 days after surgery. Bukuryo-in treatment improved submucosal edema of the anastomosis compared with water treatment. There was no significant difference in the volume of the gastric remnant or pH of the gastric juice among the three groups. These results suggest that Bukuryo-in decreases submucosal edema of the anastomosis, and Bukuryo-in treatment promptly improves stenotic symptoms.

Key words
Bukuryo-in, early anastomotic stenosis, submucosal edema of the anastomosis

Reprint requests
Yoshinobu Hattori Kijima Hospital
41 Ne, Matsuderamachi, Kanazawa, 920 JAPAN

Accepted
December 7, 1994

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