Effect of Percutaneous Transhepatic Right Branch of Portal Vein Embolization on Inducing Human Hepatocyte Grwoth Factor and Liver Function Thereafter

Setsuo Okada, Takashi Maeba, Hazime Maeta, Satoshi Tanaka

First Department of Surgery, Kagawa Medical School

Human hepatocyte growth factor was induced with two peaks within 24 hours after performing precutaneous transhepatic right branch of portal vein embolization (PTRPE) in the cirrhotic as well as the non-cirrhotic liver. Furthermore it was induced again with the same two phasic peaks within 24 hours after right lobectomy of the liver following the procedure. The left lobe was enlarged by 1.21 times in volume in the cirrhotic liver, and by 1.24 times in the non-cirrhotic liver on the 14th day after PTRPE. The values of ICG retention rate improved by the 14th day, and the level of serum retinol binding protein recovered by 90% of the pre-PTRPE level on the 21st day in both the cirrhotic and non-cirrhotic liver. PTRPE seemed to be effective in making the portal circulation in the liver shift into that of the post right lobectomy, and preventing rapid changes in the portal circulation after lobectomy. The most beneficial time for lobectomy seemed to be 2 to 3 weeks after the procedure.

Key words
percutaneous transhepatic portal vein embolization, human hepatocyte growth factor, liver regeneration, hepatectomy

Reprint requests
Setsuo Okada First Department of Surgery, Kagawa Medical School
1750-1 Miki-cho, Kita-gun, Kagawa, 761-07 JAPAN

Accepted
February 8, 1995

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