Taurocholate-induced Gastric Damage in Rats with Obstructive Jaundice and Biliary Drained Rats on the Side of Adaptive Cytoprotection

Tetsuya Matsuo, Iwao Sasaki, Yasuhiko Kamiyama, Hiroo Naitoh, Yuji Funayama, Seiki Matsuno

The First Department of Surgery, Tohoku University School of Medicine

To determine the effects of obstructive jaundice and biliary drainage on adaptive cytoprotection of the gastric mucosa' Sprague-Dawley rats were used and grouped as follows: 1) control group,2) jaundiced group, 3) biliary drainage group. High and low doses of taurocholate were orally administered as an irritant and mild irritant, respectively. The ulcer index was significantly higher in the jaundiced group than in both the control and drainage groups. The mild irritant decreased the ulcer index in each group compared with the irritant groups. These phenomenon were eliminated by indomethacin. The mild irritant reduced the decrease in the hexosamine content of the gastric mucosa induced by the irritant, and enhanced recovery of the gastric potential difference level after administration of the irritant. We conclude that gastric mucosal adaptive cytoprotection occurs even in obstructive jaundice and biliary drainage. Prostaglandin may play an important role in these mechanisms.

Key words
adaptive cytoprotection, taurocholate, hexosamine, gastric mucosal potential difference, intragastric PH

Reprint requests
Tetsuya Matsuo The First Department of Surgeyr, Tohoku University School of Medicine
1-1 Seiryoumachi, Aoba-ku, Sendai, 980 JAPAN

Accepted
March 8, 1995

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