An Experimental Study on Liver Hyperthermia Using Intraperitoneal Hyperthermic Perfusion

Tetsushi Kitagawa, Yonson Ku, Yoichi Saitoh

First Department of Surgery, Kobe University School of Medicine

We evaluated the efficacy of intraperitoneal hyperthermic perfusion (IPHP) in regional hyperthermia of the liver. In beagles (n=6), an infusion catheter (14 F) and drainage catheters (12 F) were placed in the upper abdominal cavity and the Douglas pouch, respectively. Physiological saline (46-48°C) was infused into the abdominal cacity at a flow rate of 100-300 ml/min through blood warmer coils in a water bath (47-52°C). The temperature was continuously monitored at seven measuring points including water bath, peritoneal inflow line, abdominal cavity, liver parencyma (5 mm and 30 mm in depth), portal vein and rectum. The mean temperature of the abdominal cavity reached 41.6°C 20 minutes after the start of IP HP and was stabilized in a range of 42.6 to 42.7°C after 40 minutes. The temperatures of the portal venous blood and liver parencyma (30 mm in depth) increased similarly and were kept in a range of 42 to 42.5°C after 45 minutes. On the other hand, the temperature of the rectum remained less than 40.4°C throughout the course. In conclusion, IPHP is a simple and effective method that permits optimum heating of the liver parenchyma in hyperthermia.

Key words
regional liver hyperthermia, intraperitoneal hyperthermic perfusion

Reprint requests
Tetsushi Kitagawa First Department of Surgery, Kobe University School of Medicine
7-5-2 Kusunokicho, Chuoku, Kobe, 650 JAPAN

Accepted
March 8, 1995

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