Serum Interleukin 6 and Interleukin 1 Receptor Antagonist Response in Patients after Laparoscopic and Open Cholecystectomy

Nobuo Murata, Akio Odaka, Masakazu Tada, Yasuo Idezuki

The Second Department of Surgery, Saitama Medical Center, Saitama Medical School

We have compared metabolic and inflammatory response to surgical injury between laparoscopic cholecystectomy (LC) and open cholecystectomy (OC). Interleukin 6 (IL-6), interleukin 1 receptor antagonist (IL-lra), C-reactive protein (CRP) and body temperature were measured from just after the skin incision up to 72 hours. IL-6 concentrations were elevated just after surgery. The IL-6 concentrations in OC patients were 53.3 ± 28.0 pg/ml (mean ± SD), 31.6 ± 12.3 pg/ml 29.0 ± 12.8 pg/ml and 27.4 ± 10.9 pg/ml, 4 , 8, 12 and 24 hours after the skin incision, respectively. Those in LC patients were 16.2 ± 10.7 pg/ml, 16.5 ± 8.8 pg/ml, 11.0 ± 4.2 pg/ml and 9.0 ± 9.4 pg/ml, 4, 8, 72 and 24 hours after the skin incision, respectively. These concentrations in LC patients were significantly lower at every time after surgery than in OC patients. The elevations of IL-lra, CRP and body temperature were less in LC patients than OC patients. We conclude that LC reduces metabolic and inflammatory responses more than OC.

Key words
interleukin 6, interleukin 1 receptor antagonist, inflammatory reaction, surgical stress, laparoscopic cholecystectomy

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Nobuo Murata The Second Department of Surgery, Saitama Medical Center,Saitama Medical School
1981, Kamoda-Tsujido, Kawagoe, 350 JAPAN

Accepted
April 5, 1995

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