Correlation of Clinico-pathological Study with p53 Expression in the Multiple Gastric Cancer

Hiroyuki Konno, Keiji Maruyama, Yuji Maruo, Toshikazu Kanai, Iwao Matsuda, Tatsuo Tanaka, Nobuhiko Nishino, Satoshi Nakamura, Shozo Baba, Masaki Nakamura*

Second Department of Surgery, Hamamatsu University School of Medicine, National Tenryu Hospital*

We experienced, 25 synchronous multiple gastric cancer cases in 12 years in our department. Twenty-two of the patients had double cancers and 3 had triple cancers, which accounted for 6.2% of the resected cases. Among them, 11 were early multiple gastric cancers. The sex ratio and median age of the 25 patietns were 2.57/1 male/female and 63.9 years, respectively, which were higher and older than those of patients with a single gastric cancer. Macroscopically, depressed and combined types in the main lesions and depressed and flat types in accessory lesions were common. Histologically, differentiated adenocarcinoma was common (64%) and intermediate or severe intestinal dysplasia was observed in 21 cases (84%). Immunohistochemical examination 17 patients (37 lesions) revealed that p53 was expressed in 14 patients (82.4%), and in 22 of the 37 cancer lesions (59.5%). No correlation of p53 expression with any histological type or with depth of cancer invasion was found. Because heterogeneity of p53 expression among multiple cancer lesions in the same patient was observed in 8 cases (47.l%), it is suggested that the cancer lesions in the same multiple cancer patient are produced independently.

Key words
multiple gastric cancer, p53, immunohistochemistry

Reprint requests
Hiroyiki Konno Second Department of Surgery, Hamamatsu University School of Medicine
3600 Handa-cho, Hamamatsu, 431-31 JAPAN

Accepted
June 14, 1995

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