Immunohistochemical Examination of Lymphocyte Population of Regional Lymph Nodes in Patients with Gastric Cancer

La Sachi¹⁾²⁾, Masahiko Onda¹⁾, Akira Tokunaga¹⁾, Goro Asano²⁾

First Department of Surgery¹⁾ and Department of Pathology²⁾, Nippon Medical School

A study was performed to examine immunohistochemically the T- and B-lymphocyte, and S-100 protein positive cells populations of regional lymph nodes in patients with gastric cancer. Immunohistochemically, a decrease of T-lymphocytes and dendritic cells, and an increase of B-lymphocytes were observed in metastatic lymph nodes. A decrease of CD₄ positive lymphocytes and degenerative change of these cells were also observed. Changes in the level of immunologic parameters in the distribution of immunocytes in regional lymph nodes with or without metastasis may be linked to the progression of cancer.

Key words
gastric cancer, metastasis in lymph nodes, T-lymphocytes, B-lymphocytes, dendritic cell

Reprint requests
Akira Tokunaga First Depatment of Surgery, Nippon Medical School
1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113 JAPAN

Accepted
July 5, 1995

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