Crinical and Experimental Studies of Cell Damage on Transcatheter Arterial Embolization Therapy

Taiju Hashimoto

The Second Department of Sugery, Saitama Meidical School

The relationship between tissue damage in tumor and non-tumor regions following transcatheter arterial embolizsation (TAE) and active oxygen/cytokines was studied in clinical cases (n=30) and in VX2 tumor-bearing rabbits used as models of hepatic carcinoma (n=20). Body temperature, white blood cell count, AST, ALT, LDH, superoxide dismutase (SOD) activity, interleukin-6, and nitric oxide (NO) were all temporarily increased in the clinical cases 1 day after TAE, but returned to the preoperative levels on the 7th day. Stepwise regression analysis of AST, ALT, and LDH revealed that NO was most closely correlated with liver injury. In the animal study, both SOD activity and thiobarbituric acid reactive substances increased just after operation, more in the tumor region than in the non-tumor region. In the tumor region, a large amount of lipid hydroperoxide was detected as an electron spin resonance signal on the 1st postoperative day, and necrosis of the tumor region and infiltration of neutrophiles and macrophages into the surroundings were histopathologically observed. From these results, it was suggested that active oxygens would be involved in tissue damage following TAE.

Key words
transcatheter arterial embolization, active oxygens, nitric oxide, cytokine

Reprint requests
Taiju Hashimoto The Second Department of Surgery, Saitama Medical School
38 Morohongo, Moroyama, Iruma-gun, Saitama, 350-04 JAPAN

Accepted
July 5, 1995

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