Experimental Studies of the Effects of Prostaglandin E₁ Administration to Rats with Liver Dysfunction Induced by Endotoxin

Nozomi Idota, Kazuo Hatsuse, Satoshi Shouno, Tsukasa Aihara, Michinori Murayama, Yoshihiro Sakai, Hideki Aoki, Takeyuki Idei, Masayuki Nishida, Minoru Kakihara, Shouetsu Tamakuma

First Department of Surgery, National Defense Medical College

We investigated the effect of prostaglandin E₁ (PGE₁) on rats with liver dysfunction induced by endotoxin. The dose of PGE₁ did not exceed 0.1 µg/kg/min, which did not affect the circulation adversely. The rats were divided into three groups as follows: the Ex-group was given endotoxin alone; the Ex + 0.02 PGE₁-group was given endotoxin and 0.02 µg of PGE₁; the Ex + 0.1 PGE₁-group was given endotoxin and 0.1 µg of PGE₁. We compared the liver function (T-Bil, GPT, LDH, ALP), arterial blood pressure (BP) and liver tissue blood flow (TBF) in these groups. In the Ex + PGE₁-group liver function was exacerbated though in the Ex + 0.02 PGE₁-group T-Bil was improved. BP and TBF showed little difference among these groups. These results suggested that both doses of PGE₁ had an adverse effect on liver dysfunction induced by endotoxin.

Key words
endotoxin, liver dysfunction, prostaglandin E₁

Reprint requests
Nozomi Idota First Department of Surgery, National Defense Medical College
3-2 Namiki, Tokorozawa-shi, Saitama-ken, 359 JAPAN

Accepted
November 15, 1995

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