Expression of p53 and Ki-67 Proliferative Activity on Colonic Villous Tumors -Comparison with Cases of Cancer in Adenoma and Advanced Cancer of the Colon-

Makoto Ikenaga, Yoshimasa Ohtani, Osamu Naitou, Hiroshi Sasamoto, Yoshiki Hiki, Akira Kakita

Department of Surgery, Kitasato University School of Medicine

Ten cases of colonic villous tumors composed of 10 villous adenoma components and 5 villous carcinoma components were investigated in terms of p53 expression and Ki-67 proliferative activity to determine their biological characteristics on the basis of comparison with 18 cases of cancer in adenoma and 39 cases of advanced cancer. Over expression of p53 was detected in none of the villous adenoma components, in 20% of the villous carcinoma components and in 33% of adenomas and 61% of carcinomas in patients with cancer in adenoma, Ki-67 lalbeling indices of the villous adenoma components were significantly lower than those of any carcinomas examined in the present study, and also significantly lower than those of adenomas in patients with cancer in adenoma. However, the villous carcinoma components had an index similar to that of carcinoma of patients with cancer in adenoma. These findings suggested that the villous adenoma component has a low grade malignant potential compared with adenoma in patients with cancer in adenoma in terms of over expression of p53 and the Ki-67 labeling index. In contrast, villous carcinoma has a diverse malignant potential different from that of villous adenoma, but resembling that of carcinoma in patients with cancer in adenoma.

Key words
villous tumor, p53, Ki-67

Reprint requests
Makoto Ikenaga Department of Surgery, Kitasato University School of Medicine
1-15-1 Kitasato, Sagamihara, 228 JAPAN

Accepted
November 15, 1995

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