Gastroenterological Surgery in Eight Schizophrenic Patients who Underwent Long-Term Administration of Antipsychotic Agents

Kazuya Miyoshi, Takeshi Matsui, Junichi Gangi, Susumu Shinoura, Kunzo Orita*

Department of Surgery, Municipal Shuso Hospital
*First Department of Surgery, Okayama University Medical School

We performed gastroenterological surgery on eight schizophrenic patient administrated antipsychotic agents for more than 20 years during a period of three years from 1992 through 1994. All of the operations were performed under general anesthesia induced by enflurane or isoflurane. Two postoperative complications were observed in two patients each. One was insufficiency of choledeochojejunostomy and the other was paralytic ileus. There were no suddedn deaths, regarded as the most serious adverse effect of antipsychotic agents. Oral administration of antipsychotic agents was continued until the day before surgery except for one patient with intestinal obstruction due to cancer of the transverse colon. An intramuscular or intravenous preparation of antipsychotic agents just before bedtime was given from the day after the operation and oral administration with meals was restarted. A postoperative paranoid state was found in four patients, but was not too troublesome for surgical treatment. We could perform the surgical procedure for schizophrenic patinets satisfactorily with mental management by the psychiatrists.

Key words
schizophrenia, gastroenterological surgery, antipsychotic agent

Reprint requests
Kazuya Miyoshi Department of Surgery, Municipal Shuso Hospital
131 Nyugawa, Toyo, 799-13 JAPAN

Accepted
February 14, 1996

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