The Effects of Human Angiotensin II Induced Hypertension Chemotherapyy for Liver Metastasis in the Rats

Shigeru Sakai

Third Department of Surgery, Faculty of Medicine, University of Tokyo

To determine the efficacy of angiogensin II induced hypertension chemotherapy (IHC), AH100B tumor tissue was implanted on the surface of the rat liver. Angiogensin II induced a 55% increase in the mean arterial blood pressure compared to the basal values, and the tissue blood flow of the liver tumor was increased from 56.2 ± 16.4 ml/min/100 g to 88.7 ± 35.3 ml/min/100 g as measured by an electrolytic hydrogen gas clearance method (p<0.05) . The mean tissue adriamycin concentrations of the tumor in the IHC group was four times higher than that in the normotension group. Nine days after the treatment, one case in the IHC group (n=6) showed an obvious tumor suppression effect based on the maximum size and the mean weight of the liver tumors in the IHC group was significantly decreased compared with the control group (1.317 ± 1.007 ng/g vs 3./027 ± 0.362 ng/g, p<0.05) . In conclusion, induced hypertension chemotherapy, which demonstrated accumulation of an anticancer drug selectively in tumor tissue, is considered to an effective drug delivery system for metastatic liver tumors.

Key words
angiotensin II-induced hypertension chemotherapy, drug delivery system, hydrogen gas clearance method, tissue adriamycin concentration, rat hepatic metastasis model

Reprint requests
Shigeru Sakai Third Department of Surgery, Faculty of Medicine, University of Tokyo
3-28-6 Mejirodai, Bunkyo-ku, Tokyo, 112 JAPAN

Accepted
May 8, 1996

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