Nuclear DNA Content as a Prognostic Factor in Gastric Cancer Invading to Proper Muscle Layer

Atsuo Tsuchiya, Youichi Kikuchi, Rikiya Abe, Hiroshi Mizunuma, Masashi Kanazawa, Hisayoshi Sato, Yoshiro Ando, Tadashi Nomizu, Tsuneyuki Yoshida

Department of Surgery II, Fukushima Medical College

We investigated clinicopathologically gastric cancer invasion into the proper muscle layer (mp), and the relation of flowcytometric DNA content to prognosis was determined. There was no correlation between DNA ploidy and clinicopathological variables, such as age, gender, location, macroscopic type, histology, nodal status, peritoneal metastasis, liver metastasis and staging. Fifty-nine percent of the cancers were dipolid and 41% were aneuploid, and the 5-year survival rates were 89% and 50%, respectively. Nodal status, DNA ploidy and liver metastasis were the significant prognostic variables in a univariate analysis, and the first two were also significant in a multivariate analysis. The DNA ploidy pattern in mp gastric cancer is considered to be an independent prognostic factor.

Key words
gastric cancer, DNA ploidy pattern, flow cytometry, survival, multivariate analysis

Reprint requests
Atsuo Tsuchiya Department of Surgery II, Fukushima Medical College
1 Hikarigaoka, Fukushima, 960-12 JAPAN

Accepted
October 9, 1996

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