Significance of Diagnosis of Liver Metastases from Colorectal Cancer by Angio Helical CT and Intermittent Hepatic Arterial Infusion Chemotherapy after Hepatic Resection in Terms of Prognosis

Kazuo Hatsuse, Hideki Aoki, Michinori Murayama, Yuu Shigemasa, Yasuhiro Oobuchi, Nozomi Idota, Hideki Ueno, Minoru Kakihara, Hidetaka Mochizuki, Shoetsu Tamakuma

First Department of Surgery, National Defense Medical College

Seventy five cases had undergone hepatic resection for liver metastases from colorectal cancer from 1979 to 1994. Computed tomography during hepatic angiography (angio CT) was tried in 27 cases. At first, we compared detection ratios of angio CT for liver metastase to those of ultrasonography, conventinal CT, and operative ultrasonography on these 27 cases. Next, the prognosis of seventy five cases was examined. They were divided into three groups: the HX group 29 cases with only hepatic resection: the HX+AP group of 19 cases with intermittent hepatic arterial infusion chemotherapy after hepatic resection: the angio CT group of 27 cases selected for hepatic resection by angio CT, followed by the same infusion chemotherapy as that given to the HX+AP group. Fifty metastases were diagnosed histopathologically in twenty seven cases that underwent hepatic resection after angio CT. Detection ratios for small metastases 1.0 cm or smaller in diameter were 8.3% with ultrasonography, 25% with CT, 75% with angio CT, and 50% with operative ultrasonography. Detection ratios of angio CT were superior to those of utrasonography and CT. Recurrence rates of the remnant liver were significantly low and survival rates were significantly superior in the angio CT group compared to the other two groups (p<0.02) . The prognosis with and without intermittent hepatic arterial infusion chemotherapy after hepatic resection were significantly different (p<0.03). The above data suggest that improvement of detection ratios for liver metastases by angio CT, and probably concomitant intermittent hepatic infusion chemotherapy contribute to decreased remnant liver recurrence and an increased survival rate.

Key words
hepatic metastases from colorectal cancer, computed tomography during arterial portography and hepatic arteriography, intermittent hepatic arterial infusion chemotherapy, recurrence rates of the remnant liver, survival time after hepatic resection

Reprint requests
Kazuo Hatsuse First Department of Surgery, National Defense Medical College
3-2 Namiki, Tokorozawa, 359 JAPAN

Accepted
October 9, 1996

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