A Patient with Hemophilia A in Whom Total Gastrectomy -Using Recombinant Factor VIII-

Masafumi Ogawa, Yukio Nishiguchi, Takafumi Yamashita, Kenichi Yanagawa, Michio Sowa, Motofumi Hiyoshi¹⁾

The First Department of Surgery, Osaka City University Medical School
Department of Hematology, Osaka City University Medical School¹⁾

Hemophilia A is a very rare disease and surgeon have the little patient with surgical disease. Since 1970, factor VIII concentrates was made available, hemostatic control has been straight forward easy and major surgery may be performed safely. In 1993, recombinant factor VIII was developed, but no case report of major surgery under supplementation of recombinant factor VIII have been published. We performed a successful total gastrectomy in a hemophilia A patient with gastric cancer under supplementation with recombinant factor VIII. Transfusion of recombinant factor VIII allowed good hemostatic control during and after the operation. This method of transfusion may be very useful because there is no fear of infection with unknown viruses or known viruses such as hepatitis virus and human immunodeficiency virus (HIV), and no possible effect from allo-antigen stimulator on the immune system.

Key words
hemophilia A, total gastrectomy, recombinant factor VIII

Reprint requests
Masafumi Ogawa The First Department of Surgery, Osaka City University Medical School
1-5-7 Asahimachi, Abeno-ku, Osaka, 545 JAPAN

Accepted
October 9, 1996

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