Changes and the Control of Inflammatory Cytokines of Perioperative Periods with Hepatic Resection -Effects of Preoperative Administration of the Cortico-steroids-

Hiroshi Kuzu, Yukiko Kuzu*, Shuichi Ishiyama, Akira Fuse, Joji Tanaka, Yukio Igarashi, Masahiro Urayama, Hideki Isobe, Masaru Tsukamoto

First Department of Surgery and Second Department of Internal medicine*, Yamagata University School of Medicine

Serum interleukin-6 (IL-6) levels of 16 patients who underwent hepatic resection were measured during the perioperative period. Sixteen patients with non-cirrhotic livers were divided into two groups. The steroid group (S-group: n=7) received preoperative administration of methylpredonisolone (250 mg/body) was compared with a control group (C-group: n=9) as to the levels of IL-6 and other factors in order to determine the effect of steroids. There was no difference of preoperative background between two groups. The postoperative levels of IL-6 of S-group were suppressed in comparison with C-group. The peak levels of IL-6 of S-group were significantly lower than those of C-group. Two out of the 7 patients in S-group (28.6%) had some complications after the operation, whereas 6/9 (66.7%) patients in C-group had complications. S-group showed a tendency of not only keeping a good level of respiratory function but also inhibition of liver damage after the operation. These results suggest that preoperative administration of a steroid could control the excessive reactions after hepatic surgery.

Key words
perioperative management of hepatic resection, interleukin-6, preoperative administration of methylpredonisolone, complications after hepatic resection

Reprint requests
Hiroshi Kuzu First Department of Surgery, Yamagata University School of Medicine
2-2-2 Iida-Nishi, Yamagata, 990-23 JAPAN

Accepted
November 13, 1996

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