The Effect of Perioperative Administration of Protease Inhibitor in Reducing Surgical Stress for Esophageal Carcinoma Resection

Suefumi Aosasa, Satoshi Ono, Takashi Ichikura, Hoshio Hiraide, Hidetaka Mochizuki, Shoetsu Tamakuma

First Department of Surgery, National Defense Medical College

The purpose of this study is to investigate the effect of a perioperative administration of protease inhibitor in reducing surgical stress. The effectivensss was examined from the viewpoint of the systemic inflammatory response syndrome (SIRS) and plasma cytokine levels. The patients who underwent esophageal resection were divided into two groups: (1) gabexate mesilate was administered immediately post-operatively: (2) administration of the same drug was started pre-operatively and administered through and after the operation (peri-operatively and administered through and after the operation (peri-operatively). The peri-operative group showed lower heart rate, and recovered from SIRS earlier than the post-operative group. Plasma interleukin-6 levels, interleukin-8 levels, and serum C-reactive protein levels were lower in the peri-operative group than in the post-operative group. The results indicate the reduction of surgical stress by peri-operative gabexate mesilate administration.

Key words
gabexate mesilate, surgery for esophageal carcinoma, surgical stress, cytokine, systemic inflammatory response syndrome

Reprint requests
Suefumi Aosasa First Department of Surgery, National Defence Medical College
3-2 Namiki, Tokorozawa, 359 JAPAN

Accepted
November 13, 1996

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