Experimental Study of Effective Regional Infusion Chemothrapy of Rabbit VX-2 Hepatic Implants

Yoshihisa Koyama

The Second Department of Surgery, Fukushima Medical College

This study was performed to investigate the effective route of administration of Adriamycin (ADR) combining with ADR solution or lipiodol to hepatic VX-2 tumor in the Japanese white rabbit and after intraarterial and intraportal infusion of ADR, the concentrations in the tumor, various organs and blood levels were measured. The intraarterial administration was resulted in significantly greater tumor uptake of ADR. The phamacological efficasy uptake of ADR in the three kinds of intrarterial infusion was compared among the following three groups: Group 1, administration of ADR aqueous solution alone, Group 2, administration of ADR aqueous solution between lipiodol injections (sandwich group), Group 3, ADR suspended in lipiodol (Lip-Uro-ADR group). ADR concentrations of the blood, the tumor and the organs were evaluated among the three groups. The ADR level of the tumor was significantly (p<0.01, p<0.02) higher in Group 3 than in the other groups. But, no significant difference was seen in the ADR levels of each organ among the three groups. These results suggest that the intraarterial infusion of ADR into a hepatic tumor may be the most the effective route and that a lipiodol-urografin ADR emulsion may enhance the therapuetic effects by increasing ADR uptake by the liver tumor.

Key words
liver tumor, hepatic arterial infusion, adriamycin, lipiodol

Reprint requests
Yoshihisa Koyama The Second Department of Surgery, Fukushima Medical College
1 Hikarigaoka, Fukushima, 960-12 JAPAN

Accepted
December 11, 1996

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