A Study for Cytological Behavior of Colorectal Carcinoma from the Viewpoint of Histological Type and Ki-67 Labeling Index in the Infiltrated Region of Tumor

Kimihiko Funahashi¹⁾, Kazunori Tsujita²⁾, Toshitsugu Miki²⁾, Junichi Koike²⁾, Tadahisa Ogai¹⁾, Yasushige Nagasawa²⁾, Kazuo Kobayashi²⁾, Kenzo Yanagita²⁾, Toshifumi Yoshio²⁾

¹⁾Department of Surgery, General Kawasaki Central Hospital
²⁾First Department of Surgery, Toho University School of Medicine

We determined the histological type and Ki-67 labeling index (Ki-67 LI) in the infiltrated region of 56 colorectal cancers (Dukes A: 9 cases, B: 15 cases, C: 18 cases, D: 14 cases). The results were as follows: 1) Histological heterogeneity was shown in 33.9%, and the histological type changed to a lower grade in the deepest region of the tumor. 2) The tumor with a lower grade of histological type or with mucin was postulated to be more malignant in view of the proliferating activity of the tumor cells. 3) The rate of proliferation of a tumor with regional lymph-node metastasis or with vessel invasion was higher than that of a tumor without them. Therefore, we believe that determination of the grade of the histological type and proliferating activity in the infiltrated region is important, when we determine the grade of malignacy of colorectal cancer.

Key words
colorectal carcinoma, histological heterogeneity, Ki-67 labeling index, infiltrated region

Reprint requests
Kimihiko Funahashi Department of Surgery, General Kawasaki Central Hospital
6-11-1 Omorinishi, Ota-ku, Tokyo, 143 JAPAN

Accepted
November 13, 1996

To read the PDF file you will need Abobe Reader installed on your computer.