Surgical Procedure and Genetic Diagnosis for Hereditary Nonpolyposis Colorectal Cancer

Tadashi Nomizu¹⁾, Fumiaki Watanabe¹⁾, Yoshio Yamaki¹⁾, Atsuo Tsuchiya²⁾, Rikiya Abe²⁾, Takeo Iwama³⁾, Joji Utsunomiya⁴⁾, Syozo Baba⁵⁾, Michiko Miyaki⁶⁾, Yasuhito Yuasa⁷⁾

¹⁾Department of Surgery, Hoshi General Hospital
²⁾The Second Department of Surgery, Fukushima Medical College
³⁾The Second Department of Surgery, Tokyo Medical & Dental University
⁴⁾The Second Department of Surgery, Hyogo Medical College
⁵⁾The Second Department of Surgery, Hamamatsu Medical College
⁶Department of Biochemistry, Tokyo Metropolitan Institute of Medical Science
⁷⁾Department of Hygiene & Oncology, Tokyo Medical & Dental University

One of the characteristic clinical features of hereditary nonpolyposis colorectal cancer (HNPCC) is an increased fequency of multiple colorectal cancers or synchronous or metachronous occurrence of endometrial cancer. Extensive surgical procedures involving total or subtotal resection of the large bowel with or without hysterectomy are required to achieve the best surgical outcome for HNPCC. Extended operations, however decrease the patient's quality of life. The indications for extended operation are thus determined precisely by genetically diagnosing germline mutations in i.e., hMSH2, hMLH1 or replication errors in tumors.

Key words
hereditary nonpolyposis colorectal cancer, genetic diagnosis, surgical procedure

Reprint requests
Tadashi Nomizu Department of Surgery, Hoshi General Hospital
2-1-16 Omachi, Koriyama, 963, JAPAN

Accepted
December 11, 1996

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