Retrospective Studies on Multiple Modalities of Therapy for Advanced Gastric Cancer with Peritoneal Metastasis from the Aspect of Patient Prognosis and Outpatient Interval

Takeo Kosaka, Jun-ichi Sugaya, Shigeru Yoshida, Yasuharu Nakano, Shigeki Takashima

Department of Surgery II, Kanazawa Medical University

We investigated whether multiple modalities of therapy for advanced gastric cancer with peritoneal metastasis could lengthen the patient's survival time and outpatient interval. Between 1984 and 1995, 108 patients undergoing surgery for gastric cancer at our department were found to have peritoneal metastasis. With generalized Wilcoxon test, gastrectomy, postoperative chemotherapy (POC), performance status (PS), age, operative peritoneal chemotherapy (OC), nodal status (N) and peritoneal status (P) showed significant differences. Multivariate analysis with Cox's proportional hazard model showed gastrectomy, POC, P, OC and sex are significantly potent prognostic factors. In the aspect of home care duration, age, PS, complications, preoperative chemotherapy, N, gastrectomy and OC showed significant differences. These results suggests that gastrectomy and chemotherapy in the perioperative period might be useful for gastric cancer with peritoneal metastasis.

Key words
gastric cancer, surgery, chemotherapy, peritoneal metastasis, outpatient therapy

Reprint requests
Takeo Kosaka Department of Surgery II, Kanazawa Medical University
1-1 Daigaku, Uchinada, Kahokugun, 920-02 JAPAN

Accepted
February 12, 1997

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