A Case of a Granulocyte-Stimulating Factor Producing Gastric Carcinoma

Takayuki Aimoto¹⁾²⁾, Hatsuo Yoshida, Nobuatsu Koyama, Mitsuhiro Nihei, Mitsuaki Sakonji¹⁾, Masahiko Onda²⁾

¹⁾Department of Surgery, Tsuboi Hospital ²⁾First Department of Surgery, Nippon Medical School

A 55-year-old man was admitted to our hospital because of anorexia. The laboratory data on admission showed marked leukocytosis (21200/mm³). Upper gastrointestinal X ray and endoscopic examination revealed a type 2 gastric cancer at the antrum of the stomach. The patient underwent distal gastrectomy with D₂ lymph node dissection on October 30, 1995. Surgical stage grouping was T₂, N₂, P₀, H₀, Stage IIIa. The lesion, measuring 110×90 mm, was type 5T2 according to macroscopic classification. Pathologic findings were pap, ss, ly₃, v₃ and n₂. From the 3rd day after the operation to the 28th day, the leukocyte count and the level of G-CSF in serum fell from 19200/mm³ to 7200/mm³ and 195 pg/ml to 60 pg/ml, respectively. The postoperative course was good. The patient was discharged from our hospital on February 20, 1996. Immunohistochemical study showed positive staining for G-CSF within the cytoplasm of the tumor cells. A diagnosis of a G-CSF-producing gastric carcinoma was made from these findings. There have been only 7 cases of a G-CSF-producing gastric carcinoma in Japan, including ours.

Key words
granulocyte-colony stimulating factor, gastric carcinoma

Reprint requests
Takayuki Aimoto Department of Surgery, Tsuboi Hospital
1-10-13 Nagakubo, Asaka-machi, Kooriyama-shi, 963-01 JAPAN

Accepted
April 23, 1997

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