A Clinicopathological Study of Mucous Nodule Referred to as Mucinous Component (MUC) in Colorectal Submucosal Invasive Carcinomas

Satoshi Okabe, Takehiro Arai, Shouji Maruyama, Munenari Lee, Naoya Murase, Masahiro Tsubaki, Mitsuo Endo

First Department of Surgery, School of Medicine, Tokyo Medical and Dental University

We investigated the significance of mucous nodule, termed mucinous component ("MUC"), ahead of invasion of submucosal invasive carcinoma of the colon and rectum. Chiefly, we studied the correlation between adverse pathological prognostic factors and stainability of "MUC" for mucosubstances and tumor-associated glycoconjugates. As a result of this study, we concluded that "MUC" in colorectal submucosal invasive carcinoma would be one of the important adverse prognostic factors because submucosal invasive carcinoma with "MUC" was generally accompanied by risk factors for metastasis and strong stainability of CEA and UEA-1 particularly in "MUC" concomitant with cancer cells showing a high grade atypia.

Key words
early invasive colorectal cancer, the extent of invasion, mucinous carcinoma, mucinous component

Reprint requests
Satoshi Okabe First Department of Surgery, Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku, Tokyo, 113 JAPAN

Accepted
June 11, 1997

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