Effect of Continuous Intaarterial Injection of Thromboxan A₂ Synthetase Inhibitor on the Canine Experimental Acute Pancreatitis

Kouichiro Hasegawa

First Department of Surgery, St. Marianna University School of Medicine

A selective thromboxan A₂ (TXA₂) synthetic enzyme inhibitor, CV-4151, was injected into an bile-induced acute pancreatitis model in dogs. Mongreal adult dogs were divided into 4 groups (group 1, untreated control: group 2, one-shot intravenous injection: group 3, continuous intravenous injection: group 4, continuous intraarterial injection) and the relative efficacy of each method of administration and the effects of CV-4151 were cmpared among the groups. Pancreatic tissue was harvested before and 1 and 3 hours after the induction of pancreatitis, and the levels of phospholipase A₂ (PLA₂), thromboxan B₂ (TXB₂) and 6-keto-PGF_1α in the tissue were measured. The survival rate for each group was determined. The results showed that PLA₂ and TXB₂ were suppressed significantly after 1 and 3 hours in group 4 and 6-keto-PGF_lα was suppressed significantly after 3 hours in group 4. Group 4 showed the highest survival rate among four groups. These findings indicate that a therapeutic effects similar to that seen in groups 2 and 3 can be expected from the continuous intraarterial injection of CV-4151. Furthermore, this method also yielded the highest survival rate.

Key words
acute pancreatitis, thromboxane B₂, prostaglandin I₂, arachidonic acid cascade

Reprint requests
Kouichiro Hasegawa First Department of Surgery, St. Marianna University School of Medicine
2-16-1 Sugo, Miyamaeku, Kawasaki, 216 JAPAN

Accepted
October 1, 1997

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