Colon Carcinoma with Multiple Serrated Adenomas, Report of a Case

Masahiro Nakahara, Masazumi Okajima, Michinori Arita, Riichiro Kobayashi, Yoshiyuki Masaoka, Yasutomo Ojima, Kazuhiro Toyota, Katufumi Kawahori, Toshimasa Asahara, Kiyoshiko Dohi

Secoond Department of Surgery, Hiroshima University School of Medicine

A 29-year-old female who had an abdominal mass of abdomen was seen at the hospital. Barium enema radiography and colonoscopy showed a carcinoma (ulcerative lesion, advanced) of transverse colon and multiple polyps. Right hemicolectomy (D3 lymph node dissection) was carried out. Histopathologically, the ulcerative lesion proved to be well differenciated adenocarcinoma with invasion to the serosa and paracolonic lymph node metastasis was found. Multiple sessile and pedunculated polyps were shown to be hyperplastic polyps and serrated adenomas. Genetic instability was investigated at 5 microsatellite loci, however replication error was not detected in neoplastic site, including serrated adenoma.

Key words
colon cancer, serrated adenoma

Reprint requests
Masahiro Nakahara Second Department of Surgery, Hiroshima University School of Medicine
1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JAPAN

Accepted
April 22, 1998

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