Adjuvant Chemotherapy for Colorectal Carcinoma

Katsuyoshi Hatakeyama

The First Department of Surgery, Niigata University School of Medicine

Randomized controlled study (RCS) compared with surgery alone is necessary to evaluate the significance of post-operative adjuvant chemotherapy for colorectal carcinoma. In this paper, I introduced a part of the results of our department by historical study, and mainly described the results of the national RCSs for adjuvant chemotherapy. The results of a study groups have been reported up to now. In adjuvant chemotherapy for colonic carcinoma, all of 6 study groups showed no significantly better survival rates. In adjuvant chemotherapy for rectal carcinoma, only 2 groups of them showed significantly better survival rates. Further RCSs which change the variety and combination of anti-cancer agents, or use the biochemical modulation together are required.

Key words
adjuvant chemotherapy for colorectal carcinoma, randomized controlled study, biochemical modulation

Reprint requests
Katsuyoshi Hatakeyama The First Department of Surgery, Niigata University School of Medicine
1-757, Asahimachi-dori, Niigata, 951-8510 JAPAN

Accepted
May 19, 1998

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