Immunohistochemical Study of HSC73, RB and Ki-67 Expression in Esophageal Squamous Cell Carcinomas

Kenichi Sakurai, Satoshi Hata, Sadao Amano and Masahiro Fukuzawa

1st Department of Surgery, Nihon University School of Medicine

We examined the immunohistochemical expressions of HSC73 RB protein and Ki-67 in samples of esophageal squamous cell carcinoma from 64-cases, and these expressions were studied along with clinicopathologic factors and the survival rate. The expressions of the HSC73 and RB were recognized in 47.9% and 70.4% respectively, while the average of Ki-67 positive ratio was 53.3%. The expressions of HSC73 were more prominent in well differentiated or moderately differentiated carcinomas in comparison with those in poorly differentiated cancers. Survival rate was significantly worse in the patients with HSC73 negative tumors than in those with HSC73 positive tumors. The expression of RB did not relate to histologic classification, growth pattern, and lymphatic invasion. The RB positive and HSC73 negative groups revealed the lower Ki-67-PI than RB positive and HSC73 positive proups. We guessed that cell cycle regurators were stabilized with HSC73 in squamous cell carcinoma of the esophagus.

Key words
esophageal cancer, heat shock protein, heat shock cognate protein 73, retinoblastoma protein, Ki-67 antigen

Reprint requests
Kenichi Sakurai First Department of Surgery, Nihon University School of Medicine 30-1 Oyaguchi, Itabashi, Tokyo, 173-8610 JAPAN

Accepted
December 9, 1998

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