A Case of Malignant Schwannoma with Gastric Metastasis

Chika Shigemori, Tetsuya Ikeda, Hiroshi Yamagiwa^* and Hiroshi Suzuki^**

Department of Surgery, Kusaka Hospital
Laboratory Services Department^*, Department of Surgery II^**, Mie Medical School

We present a very rare case of malignant schwannoma with gastric metastasis. A 54-year-old woman was admitted to the Department of Orthopedics due to local recurrence of malignant schwannoma in the left upper arm associated with lung metastasis. She underwent amputation of the left upper arm at 44 years of age. Examination of the severe anemia (Hb 4.5g/ml), as well as upper gastrointestinal fiberscopy (GIF) and upper gastrointestinal tract series (UGIS) were performed in our department. The findings showed a large tumor with ulceration in the stomach, but pathological findings from the biopsy specimen suspected poorly differentiated adenocarcinoma. Surgery was performed with a pre-operative diagnosis of gastric cancer and malignant schwannoma in the left upper arm. The tumor arose from the submucosal layer of the stomach, and occupied the antrum. Microscopic findings confirmed the diagnosis of malignant schwannoma in the left upper arm. The results of immunohistochemical staining of the specimens from the left upper arm and the stomach were also the same: S-100 protein (-), NSE (+). The final diagnosis was malignant schwannoma with gastric metastasis.

Key words
malignant schwannoma, gastric metastasis

Reprint requests
Chika Shigemori Department Surgery II, Mie Medical School 2-174 Edobashi, Tsu-city, 514-8507 JAPAN

Accepted
February 24, 1999

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