A Case of Hepatocellular Carcinoma with Erythrocytosis

Taichirou Satou, Takatoshi Matsumoto, Shigeaki Moriura, Junichi Nagata, Yuuichi Takayama, Atsushi Hirano and Seiji Ishiguro

The Department of Surgery, Yachiyo Hospital

A case of erythropoietin producing hepatocellular carcinoma is presented. A 64-year-old man was referred to the hospital because of a hepatic tumor and erythrocytosis. CT showed a large hepatic tumor in the right lobe and ultrasonography demonstrated tumor thrombus in the inferior vena cava. His serous erythropoietin level was elevated to 1,510 mU/ml. Trans arterial chemotherapy was not effective and the patient died of the tumor on the 61st hospital day. Necropsy of the hepatic tumor revealed hepatocellular carcinoma of a trabecular type and immunohistochemistory for erythropoietin was strongly positive. Eight cases of hepatocellular carcinoma with erythrocytosis in the Japanese literature are reveiwed.

Key words
erythropoietin producing hepatocellular carcinoma

Reprint requests
Taichirou Satou The Department of Surgery, Yachiyo Hospital 1-10-13 Touei-cho, Anjo-shi, 446-8510 JAPAN

Accepted
May 25, 1999

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