The Preventive Effect of Dai-saiko-to, Sho-saiko-to and Inchin-go-rei-san Extracts on Gallstone Formation after Truncal Vagotomy in Hamsters

Manabu Shiozawa, Toshio Imada, Ryuji Shiraishi^*, Takashi Oshima, Yasushi Rino and Yoshinori Takanashi

First Department of Surgery, Yokohama City University, School of Medicine

^*Department of Surgery, Hiratsuka Kyosai Hospital

This study was conducted to evaluate the preventive effect of chinese medicine of Dai-saiko-to (CM-8), Sho-saiko-to (CM-9) and Inchin-go-rei-san (CM-117) on gallstone formation after truncal vagotomy in the hamster. Gallstone formation was observed in 100% of the control hamsters and 50% of those treated with CM-8, 55.6%with CM-9 and 62.5%with CM-117. Total bile acid concentration in the gallbladder bile was lower in the CM-8 group and higher in the CM-9 and TJ-117 groups. In the molecular forms of bile acids, the ratios of cholic acid to chenodeoxycholic acid (CA/CDCA) and secondary bile acid to primary bile acid (S/P) were improved in the CM-9 and CM-117 groups. However, it was not improved in the CM-8 group. The preventive effect of the extracts on gallbladder stone formation was closely related with biliary constituents and the melecular forms of bile acids in the CM-9 and CM-117 groups. In the CM-8 group, the preventive effect might be dependent upon other factors.

Key words
chinese medicine, gallstone formation after vagotomy

Reprint requests
Manabu Shiozawa First Department of Surgery, Yokohama City University, School of Medicine 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JAPAN

Accepted
September 22, 1999

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