A Case of Cancer in Adenoma Arising in Brunner's Glands

Tsuyoshi Shinohara, Masaki Terasaki, Takao Kuno, Yasukatsu Okamoto, Eiji Sakamoto, Satoshi Kamiya, Satoshi Kobayashi, Yutaro Asaba and Shouji Hoshi^*

Department of Surgery, Shizuoka Saiseikai General Hospital
^*Department of Pathology, Shizuoka Saiseikai General Hospital

A 71-year-old man with no complaint was referred to tur hospital because of a subpedunculated tumor at the opposite side of Vater's papilla, which was detected by upper gastrointestinal endoscopy during screening. Hypotonic duodenography revealed a subpedunculated tumor, and was diagnosed as a benign tumor of the duodenum. Incision of the duodenal wall and resection of the tumor were performed. Histological examination revealled slightly enlarged tumor cells located on the submucosal layer and proliferating in a papillary pattern, which suggested they had originated from Brunner's glands and also showed few cellular and structual atypia, which indicated adenoma. However, destruction of the muscularis mucosae and invasion to the propria mucosae, therefore, we concluded that the tumor was carcinoma arising in Brunner's glands. This case presented cancer in adenoma, so these findings seemed to propose an interesting problem in the development of carcinoma arising in Brunner's glands.

Key words
carcinoma arining in Brunner's glands, cancer in adenoma

Reprint requests
Tsuyoshi Shinohara Department of Surgery, Shizuoka Saiseikai General Hospioal 1-1-1 Oshika, Shizuoka city, 422-8527 JAPAN

Accepted
November 30, 1999

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