A Case of Hepatocellular Carcinoma with Resection of Pulmonary Metastases after Systemic Chemotherapy

Haruhiro Nakazaki, Masashi Watanabe, Yukitake Hasebe, Natuki Tokura, Mituru Ooshiro, Wataru Takita, Toshitugu Miki, Akira Seo, Akiharu Kurihara and Kazuo Kobayashi

The First Dept. of Surgery Toho University, School of Medicine

A 61-year-old male was admitted for chronic myelocytic leukemia. Computed tomography showed a tumor 4 cm in diameter in the left lobe of the liver and a tumor 8 mm in diameter in the right lobe. The serum alfa-fetoprotein (AFP) level was 1,757 ng/ml. Left hepatic lobectomy and ethanol injection for a tumor in S8 were performed in October 1994. Multiple bilateral lung metastases were detected by chest X-P and CT scan in April 1996. Then CDDP, 20 mg (iv; for 1 hour), and 5-FU, 2,000 mg (iv; continous for 7 days) were then administered repeatedly. Six months after the administration, the AFP levels had decreased to 340 ng/ml from 5,205, and lung metastases had disappeared, except a tumor 1.5 cm in diameter in the left lung. As the tumor failed to resolvedid in spite of additional chemotherapic, wedge excision of the left lung was performed. He is alive without recurrence in lung and liver. We have reported a case of HCC in which resection of a pulmonary metastases was performed after systemic chemotherapy.

Key words
hepatocellular carcinoma, pulmonary metastases, systemic chemotherapy

Reprint requests
Haruhiro Nakazaki The First Department of Surgery, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541 JAPAN

Accepted
December 22, 1999

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