Synchronous Gastric Adenocarcinoma and MALT-type Lymphoma with Helicobacter Pylori Infection -A Case Report-

Yoshinari Mochizuki, Tatsuo Makino, Yasunobu Yamazaki, Takashi Suda, Hiroshi Takemura and Nobuko Nakamura^*

Dept. of Surg, Dept of Patology^*, Saiseikai Yakohama Southern Hospital

A 62-year-old man was referred to our hospital because of multiple gastric adenocarciomas at another clinic. Serological examination disclosed the presence of IGg antiboies to H. pylori. Endoscopy and roentgenograms of the stomach revealed a large ulcerated lesion of Borrmann 3 type in the gastric body, and an ulcerated lesion of Borrmann 2 type with some nodular areas in the antrum. Forceps biopy specimens taken from all lesions revealed that the fomer lesion was a poorly differentiated adenocarcinoma and that the latter including nodular areas were proliferation of an atypical cell. A total gastrectomy with splenectomy was performed under a diagnosis multiple gastric carcinomas August. 14th, 1997. Histological examination confirmed that the gastric body lesion was compatible with poorly differentiated adenocarcinoma of diffuse-type, with invasion to se and regional lymphnodal involvement. Furthermore, the lesions were MALT-type lymphoma. The Coexistence of gastric carcinoma and lyphoma has been considered rare. However, recent evidence suggests that H. pylori infection increases the risk of developing both gastric adenocarcinoma and MALT-type lymphoma. This necessitates a balanced attitude that focuses not only on one malignancy but also carefully observes the possiblility of other malignancies in the stomach.

Key words
gastric carcinoma, MALT-type lymphoma, helicobacter pylori infection

Reprint requests
Yoshinari Mochizuki Dept. of Surg. Gamagouri City Hospital 1-1 Mukaida, Hirata-chou, Gamagouri city, 443-8501 JAPAN

Accepted
February 23, 2000

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