A Case of Gastrointestinal Stromal Tumor of the Duodenal 1st portion

Keisuke Uehara, Hiroshi Hasegawa, Hidemasa Nagai, Seiji Ogiso, Masaya Shiomi, Masato Momiyama, Tsuyoshi Igami, Shusaku Ohira, Takeshi Amemiya and Yu Takahashi

Department of Surgery, Nagoya Daini Red Cross Hospital

A 71-year-old man was admitted to our hospital with nausea and vomiting. Upper gastrointestinal fluoroscopy showed a compression at the duodenal 1st portion without irregularity of the mucosa. Abdominal CT and MRI demonstrated a mass with size of 6 cm adjoining to the duodenum. He was diagnosed as having submucosal tumor of the duodenum and underwent partial resection of the duodenum. Histological findings showed spindle cells with funicular pattern. Immunohistochemically, the tumor showed negative for SMA (smooth muscle actin) and S-100 protein, but positive for c-kit (CD117) and CD34. Then, the tumor was diagnosed as uncommitted type gastrointestinal stromal tumor (GIST). Recently, the concept of the gastrointestinal stromal tumor has become to be popular among surgeons. This case is presented with some notes on the relevant literature.

Key words
gastrointestinal stromal tumor, duodenum, c-kit

Reprint requests
Keisuke Uehara Department of Surgery, Nagoya Daini Red Cross Hospital2-9 Myouken-cho, Shouwa-ku, Nagoya, 466-8650 JAPAN

Accepted
February 23, 2000

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