Multiple Granular Cell Tumors of the Colon

Hiromitsu Takeyama, Eiko Ohara, Yoshimi Akamo, Moritsugu Tanaka, Takuji Fukui, Tetsushi Hayakawa, Noriaki Mohri, Minoru Yamamoto, Mikinori Sato and Tadao Manabe

First Department of Surgery, Nagoya City University Medical School

The case of a 46-year-old man with multiple granular cell tumors of the colon is reported. The patient was admitted to our hospital with the chief complaint of abdominal pain. Barium enema and colono-fiberscopic examination revealed 3 submucosal tumors (SMT), 2-mm and 5-mm SMTs in the ascending colon and a 5-mm SMT in the rectum, with a large polyp in the cerum. The SMT in the rectum was removed by polypectomy, the polyp and the two SMTs in the ascending colon were resected by ileocecal resection. Histologically, the polyp showed adenoma. The three SMTs had the same histological features, composed of closely packed polygonal cells containing delicate acidophilic granules, and positive for S-100 and NSE (neuron-specific-enolase) and negative for dementin. The diagnosis of granular cell tumor was made. This is the third case report in Japan of multiple granular cell tumors of the colon.

Key words
multiple granular cell tumors, colon, S-100 protein

Reprint requests
Hiromitsu Takeyama First Department of Surgery, Nagoya City University Medical School 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601 JAPAN

Accepted
February 23, 2000

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