Proximal Cholangiocarcinoma: Prognostic Factor and Effectiveness of Post Operative Radiotherapy

Noriyuki Kamiya, Itaru Endo, Atsushi Takimoto, Yoshiro Fujii, Hitoshi Sekido, Shinji Togo and Hiroshi Shimada

2nd Department of Surgery, Yokohama City University School of Medicine

To define the prognostic factors after surgical resection and evaluate the effectiveness of Post Operative Radiotherapy (PORT) in cases with cholangiocarcinoma, 44 cases with proximal cholangiocarcinoma were examined. The mean observation period was 20.6 months, and the survival rates 1,3 and 5 years after the resection were 79.9%, 59.8% and 39.3%, respectively. Univariate analysis revealed that the presence of lymph node metastasis and absence of PORT were significant poor prognostic factors. Multivariate analysis revealed that the absence of PORT was a significant poor prognostic factor. The survival rates for 1 and 3 years after the resection were 80.0% and 40.0% in the curable A/B and PORT (-) group, and 100% and 53.3% in curable C and PORT (+) group. There were no local reccurences in the pathologically classified hm2 and em2 patients who underwent PORT. Even when the surgical margin is positive for the carcinoma pathologically, it is possible to avoid local recurrence with PORT.

Key words
proximal cholangiocarcinoma, prognostic factor, postoperative radiotherapy

Reprint requests
Noriyuki Kamiya 2nd Department of Surgery, Yokohama City University School of Medicine 3-9 Fukuura, Kanazawa-ku, Yokohama City, 236-0004 JAPAN

Accepted
June 28, 2000

To read the PDF file you will need Abobe Reader installed on your computer.