The Problem of Autologous Blood Transfusion for the Patients who Underwent Preoperative Adjuvant Chemotherapy: 5-FU and CDDP Concentration in the Preserved Autologous Blood

Yoshiyuki Hoya, Susumu Kawano, Satoshi Yamazaki, Ryuuzou Murai, Kazuo Matai and Yoji Yamazaki

Department of Surgery, The Jikei University School of Medicine

To confirm the safety of autologous blood transfusion in patients of advanced esophageal and gastric cancer undergoing preoperative adjuvant chemotherapy (5-FU: 500 mg/m²/day, continuous infusion on days 1-5 and days 8-12, CDDP: 5 mg/m²/day, drip infusion on days 1-5 and days 8-12), we analyzed 5-FU and CDDP concentration in preserved autologous blood and evaluated toxicity with changes in potassium concentration. All data on the 5-FU concentration was below the limit of measurement (<1 ng/ml). The CDDP concentration showed the effective dose from 0.55±0.25 μg/ml to 0.57±0.25 μg/ml. Changes in potassium concentration in preserved autologous blood and in non irradiated homologous blood were similar. In this study of a low-dose CDDP regimen, the CDDP concentration in preserved autologous blood apparently had no adverse effect on patients. In treatment with a high-dose CDDP regimen, however, it is important to collect autologous blood after the CDDP concentration has decreased sufficiently.

Key words
autologous blood transfusion, advanced esophageal and gastric cancer, preoperative adjuvant chemotherapy

Reprint requests
Yoshiyuki Hoya Department of Surgery, The Jikei University School of Medicine 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461 JAPAN

Accepted
December 19, 2000

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