The Effect of Vascular Closure Staple in Primary Closure of Common Bile Duct in Experimental Models

Naoto Saito, Nozomi Shinozuka and Isamu Koyama

First Department of Surgery, Saitama Medical School

Vascular closure staples (VCSs) have been developed for vascular anastomosis, and they have been shown not to penetrate into the vascular lumen. The efficacy of VCSs for direct closure of the common bile duct was evaluated in 22 rats and five rabbits. The common bile duct was ligated to induce dilatation, and direct closure with VCSs was performed seven days later. The operation time for direct closure of the common bile duct with VCSs was less than five minutes in every animal. All rats survived for 28 days, and there were no major complications, such as bile leakage or stenosis of common bile duct. The common bile ducts were harvested seven or 28 days after the closure operation, and they were examined histologically with an electron microscope. No penetration of VCS into the lumen of the common bile ducts, no wall thickening, and no immflamatory responses were seen in the bile ducts of any of the rats. These findings suggest that VCSs may be useful and effective for direct closure of the common bile duct in clinical cases.

Key words
vascular closure staple, primary closure of common bile duct

Reprint requests
Naoto Saito First Department of Surgery, Saitama Medical School 38 Morohongou, Moroyama, Iruma-gun, Saitama, 350-0495 JAPAN

Accepted
December 19, 2000

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