Synchronous Early Gastric Adenocarcinoma and MALT-lymphoma with Helicobacter Pylori Infection -A Case Report-

Hiroaki Takahashi, Takashi Tomita and Hiroki Hayakawa

Department of Surgery, Suzuka Kaisei Hospital

A 37-year-old man suffered synchronous early gastric adenocarcinoma, primary low grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), and Helicobacter pylori infection. His stomach disease was detected during a physical check up. Endoscopy and radiography of the stomach revealed widespread irregular mucosa and erosion of the antrum and body of the stomach. Forceps biopsy specimens from the lesion revealed well-differentiated adenocarcinoma with formation of a lymph follicular lesion. Total gastrectomy with splenectomy was conducted under the diagnosis of widespread early gastric carcinoma. Histological examination confirmed the gastric body lesion to be compatible with the diagnosis of well differentiated adenocarcinoma invading the mucosa. Lesions of the gastric body and antrum corresponded to MALT lymphoma invading the submucosa. Helicobacter pylori was also detected. The association of adenocarcinoma and MALT lymphoma of the stomach is rare, but these 2 neoplasms have been shown to be related to Helicobacter pylori infection. This case was important for determining the correlation of MALT lymphoma, adenocarcinoma, and Helicobacter pylori infection.

Key words
gastric carcinoma, MALT lymphoma, helicabacter pylori infection

Reprint requests
Hiroaki Takahashi Department of Surgery, Suzuka Kaisei Hospital

Accepted
February 28, 2001

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