A Case of Heterochronic Development of Extrahepatic Bile Duct Carcinoma and Cholangiocellular Carcinoma

Yoshihiro Nakakubo, Satoshi Kondo, Makoto Omi, Satoshi Hirano, Yosiyasu Ambo, Toshiaki Morikawa, Shunichi Okushiba, Hiroyuki Katoh and Michio Shimizu^*

Department of Surgical Oncology, Hokkaido University School of Medicine, Department of Surgical Pathology, Hokkaido University Hospital^*

We report a rare case of heterochronic development of extrahepatic bile duct carcinoma and cholangiocellular carcinoma. A 49-year-old woman was diagnosed with middle and lower bile duct carcinoma and pancreaticoduodenectomy and Whipple's reconstruction were conducted in June 1994. Four years later, the woman was admitted to our hospital suffering from diarrhea. Abdominal computed tomography (CT) and cholangiography revealed a liver tumor. We suspected recurrence of bile duct carcinoma in the PTBD fistula in the liver, and conducted extended left and caudate lobectomy and resectioning of the choledochojejunostomy. Histopathologically, the tumor was diagnosed as cholangiocelluar carcinoma, and clarified to be heterochronic double cancer.

Key words
bile duct carcinoma, cholangiocellular carcinoma, heterochronic development

Reprint requests
Yoshihiro Nakakubo Department of Surgical Oncology, Hokkaido University School of Medicine N15, W7, Kita-ku, Sapporo, 060-8638 JAPAN

Accepted
May 23, 2001

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