Clinical Role of Secretin loading Magnetic Resonance Cholangiopancreatography in the Patients undergoing Pancreatic Resection

Ken Simada, Tsuyoshi Takahashi, Muneki Yoshida and Akira Kakita

Depertment of Surgery, Kitasato University School of Medicine

Background: We determined factors contributing to increased signal intensity in the reconstructed jejunal loop in patients undergoing pancreatic resection, frequently observed on magnetic resonance cholangiopancreatography following intravenous injection of secretin (S/MRCP). We also evaluated the possible roles of S/MRCP in assessing the patency of pancreatojejunal anastomosis and the secretory function of the remnant pancreas. Methods: Subject were 44 patients undergoing several types of pancreatic resection. Baseline output and response to secretin of the remnant pancreas were measured after surgery. S/MRCP and pancreatic function diagnostant (PFD) tests were conducted preoperatively, and in early and late periods after surgery. Results: Baseline pancreatic output was 1.2±0.7ml/10-min, and increased after secretin load to a maximum 9.0±6.6ml/10-min in10min. Signal intensity of the jejunal loop increased in2patients versus 40 patients (95%) during the early versus late postoperative periods. During the late period, PFD was significantly higher in patients with increased signal intensity than in those without. PFD correlated well with cumulative pancreatic output following secretin loading (r=0.820). Conclusion: A major factor responsible for increased signal intensity in S/MRCP of the jejunal loop was increased pancreatic output. The increase in signal intensity was a definitive sign of patent pancreatojejunal anastomosis. S/MRCP thus seems to have a potential for evaluating the secretory function of the remnant pancreas.

Key words
magnetic resonance cholangiopancreatography, secretin, pancreatic exocrine test

Reprint requests
Ken Shimada Department of Surgery, Kitasato University School of Medicine 1-15-1 Kitasato, Sagamihara, 228-8555 JAPAN

Accepted
October 31, 2001

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