A Case of Adenocarcinoma of the Anal Canal Responded to Chemoradiotherapy

Chihiro Tanaka, Naoki Yokoo, Yasuhito Kitakado, Takashi Shiroko, Takami Fukui, Takahiro Yoshida, Katsuaki Ura, Shinya Hamasu, Hiromitsu Nagata and Kiyohisa Okamoto^*

Department of Surgery, Department of Pathology^*, Takayama Red Cross Hospital

A 54-year-old man was admitted with a 3-year history of anal bleeding on defecation and perianal pain. Physical examination showed redness, swelling, tenderness, and some disintegrated and defective regions of skin in the broad area of the buttocks and perineum. At surgical drainage, biopsy of the perianal mass showed well differentiated adenocarcinoma. He was first given an artifical stoma, followed by chemoradiotherapy. Two months later, the tumor was no longer detectabe in palpation, computed tomograhy, or magnetic resonance imaging. Miles operation with lymph node dissection was conducted, including superficial inguinal lymph nodes. Macroscopically no tumor mass was seen in the resected specimen and, histologically, only a few residual cancer regions. Tumor markers were normalized by the chemoradiotherapy. We thus consider chemoradiotherapy useful both in neoajuvat and radical treatment for selected cases.

Key words
anal cancer, adenocarcinoma, chemoradiotherapy

Reprint requests
Chihiro Tanaka Department of Surgery, Takayama Red Cross Hospital 3-11 Tenman-cho, Takayama, 506-0025, JAPAN

Accepted
October 31, 2001

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