A Case of Mesocolic and Hepatic Metastasis for 6 Years after Resection of Gastrointestinal Stromal Tumor of the Duodenum

Hitoshi Yamaie, Toshiya Ito, Fumio Kitaoka, Kaname Ishizu, Koichi Aoki and Hiroshi Ohtani^*

Department of Surgery, Youmeikai Obase Hospital
The First Department of Pathology, Nagasaki University School of Medicine^*

A 70-year-old woman underwent partial duodenectomy for duodenal gastrointestinal stromal tumor (GIST). Two solitary metastatic lesions detected in the transverse mesocolon and liver 2.2 years and 6 years after surgery were removed. Since similar pathohistological and immunohistochemical findings were obtained from these 3 tumors, the patient was diagnosed as having c-kit-, CD34-and vimentine-positive GIST. Malignancy tended to be higher in metastatic tumors than in the primary tumor. Duodenal GIST was supplied by the superior mesenteric artery and the left colica. The metastatic lesion in the mesocolon doubled in size in about 85 days. Since the patient survived 7 years after surgery, we recommed active tumor resection when metastatic lesions are detected in regular follow-up at 6-month intervals postoperatively for 10 years or more.

Key words
primary duodenal GIST, metastatic mesocolic GIST, metastatic hepatic GIST

Reprint requests
Hitoshi Yamaie Department of Surgery, Youmeikai Obase Hospital 1598 Kanda-cho, Miyako-gun, Fukuoka, 800-0344 JAPAN

Accepted
February 26, 2003

To read the PDF file you will need Abobe Reader installed on your computer.