Successful Treatment of Advanced Gastric Cancer with TS-1 Followed by Curative Gastrectomy

Motoki Hiroyoshi, Kazunori Ogino, Daisuke Kuroda, Hitoshi Moritomo, Hirofumi Fujita and Hiroshi Ogawa^*

Department of Surgery, Seirei Mikatahara Hospital
Department of Pathology, Seirei Mikatahara Hospital^*

We report the case of a 64-year-old man with gastric cancer accompanied by pyrolic stenosis, which we treated with chemotherapy using TS-1. An endocopy revealed a type-2 gastric cancer that was diagnosed as a poorly differentiated adenocarcinoma on the basis of biopsy findings. A gastrectomy was impossible because of pancreas invasion, and a gastrojejunal bypass operation was performed. The patient was treated with a daily oral administration of 120 mg of TS-1 for 4 weeks followed by 2-week rest. After one cycle of this regimen, a computed tomography (CT) examination showed the regression of the primary tumor and lymph node metastasis. After three cycles, a CT examination confirmed that the primary tumor and lymph node metastasis had disappeared. The effectiveness of the drug continued until the end of the eighth course, and surgery was performed once again. A distal gastrectomy was subsequently performed without obtaining any residual tumor findings. Chemotherapy with TS-1 is expected to be an effective method for treating advanced gastric cancer.

Key words
gastric cancer, chemotherapy, TS-1

Reprint requests
Motoki Hiroyoshi Department of Surgery, Seirei Mikatahara Hospital 3453 Mikatahara-cho, Hamamatsu, 433-8558 JAPAN

Accepted
June 25, 2003

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