A Case of Double Cancer of Hepatocellular Carcinoma and Cholangiocellular Carcinoma after Disappearance of Hepatitis C Virus

Naoko Okamoto, Kenichi Teramoto, Susumu Takamatsu, Takanori Ochiai, Takumi Irie, Norio Noguchi, Tohru Kawamura, Shigeki Arii and Toru Igari*

Department of Surgery, Division of Hepato Biliary Pancreatic Surgery,
Tokyo Medical and Dental University School of Medicine
Department of Pathology, Tokyo Medical and Dental University School of Medicine*

A 68-year-old man diagnosed with chronic hepatitis C in 1995 responded to interferon (IFN) therapy, which eliminated serum HCV-RNA in 2000. Twenty months thereafter, two tumorous lesions at S2 and S8 of the liver were detected by computed tomography. Angiography showed a hypervascular tumor at S8 and a hypovascular tumor at S2. In August 2002, transcatheter arterial embolization (TAE) was unsatisfactory for the tumor at S2. We finally diagnosed hepatocellular carcinoma at S8 and cholangiocellular carcinoma at S2. Left lateral segmentectomy and partial resection of S8 was done in August 2002. Pathologically, the tumor at S8 was hepatocellular carcinoma and that at S2 was cholangiocellular carcinoma. Concomitant hepatocellular and cholangiocellular carcinoma is rare. We herein report a case of double cancer after disappearance of the hepatitis C virus.

Key words
hepatocellular carcinoma, cholangiocellular carcinoma, double cancer

Reprint requests
Naoko Okamoto Department of Surgery, Tokyo Medial and Dental University
1-5-45 Yushima, Bunkyou-ku, Tokyo, 113-8519 JAPAN

Accepted
February 25, 2004

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