A Case of Crohn's Disease Complicated with Colonic Cancer

Munenori Nagao, Yuji Funayama, Kouhei Fukushima, Chikashi Shibata, Kenichi Takahashi, Hitoshi Ogawa, Akihiko Hashimoto, Yoshitaka Kinouchi¹⁾, Takayuki Masuda²⁾ and Iwao Sasaki

Department of Surgery, Division of Biological Regulation and Oncology (Division of GI & Colorectal Surgery), Division of Gastroenterology¹⁾, Tohoku University Graduate School of Medicine,
Division of Pathology, Tohoku University School of Health Sciences²⁾

A 29-year-old man diagnosed with Crohn's disease at age 27 underwent emergency ileostomy for an intestinal obstruction on April 5, 2001. After his general condition improved, subtotal colectomy was done on November 8, 2001, due to stenosis of the descending colon. Histological examination of the descending colon showed transmural inflammation and granulomatous change, typical of Crohn's disease. The infiltration of well-differentiated adenocarcinoma in the diseased descending colon to the subserosal layer was also observed. p53 positive mucosa without structural atypia was found around the carcinoma. Follow-up has yet to indicate recurrence.

Key words
Crohn's disease, colonic cancer

Reprint requests
Munenori Nagao Department of Surgery, Division of Biological Regulation and Oncology, Tohoku University Graduate School of Medicine
1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574 JAPAN

Accepted
February 25, 2004

To read the PDF file you will need Abobe Reader installed on your computer.