A Resected Case of Retroperitoneal Recurrence of Gastrointestinal Stromal Tumor of the Small Intestine, after Neoadjuvant Chemotherapy with Imatinib Mesylate which Remarkably Responded

Eiji Minato, Ippei Fujino, Kohei Otake, Kazuo Matsumoto and Kouichi Shima

Shingu Municipal Medical Center

A 48-year-old man admitted for an abdominal tumor in March 2002, had undergone resection for a jejunal tumor. Immunohistochemical examination showed tumor cells were positive for c-kit and CD34, but negative for S-100 and α-SMA. The tumor was diagnosed as a gastrointestinal stromal tumor (GIST) of the small intestine. He was later readmitted in September 2003 for a retroperitoneal tumor beside the right adrenal gland, 8 cm in diameter. Neoadjuvant chemotherapy with Imatinib Mesylate at a dose of 400 mg/day was administered with a diagnosis of recurrent GIST. All toxicities were mild and treatment was continued for a month. CT showed marked reduction in tumor size, laparotomy was conducted in November 2003. Histopathologically, the tumor was diagnosed as recurrent GIST.

Key words
gastrointestinal stromal tumor, Imatinib Mesylate, neoadjuvant chemotherapy

Reprint requests
Eiji Minato Shingu Municipal Medical Center
Hachibuse 18-7, Shingu, 647-0072 JAPAN

Accepted
April 28, 2004

To read the PDF file you will need Abobe Reader installed on your computer.